Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4816 | CA20370 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 24 |
| 2 | 3TC+D4T+NFV | 21 |
| 3 | 3TC+DDI+NVP | 17 |
| 4 | DDI+NVP+RTV+SQV | 17 |
| 5 | ABC+EFV+NFV | 27 |
| 6 | 3TC+ABC+AZT+IDV+RTV | 34 |
| 7 | 3TC+ABC+APV+AZT+EFV+RTV | 32 |
| 8 | 3TC+AZT+EFV+LPV | 24 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30DN | N88D | L10I, I13IV, K14R, I15V, N37D, K45KR, I62V, L63P, H69HY, V77I, L90X, I93L |
| >CA20370| codons 1-99 PQITLWQRPIVTVRVGGQLKEALLDTGADNTVLEEMDLPGRWKPRMIGGIGGFIKVRQYD QVPIEICGYKAIGTVLIGPTPVNIIGRDLXTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V | K103KN, Y181C, G190S | T27A, K32E, V35L, S68SG, V106I, K122E, S134SR, K173T, Q174R, Q207E, R211K, F214L, H221Y, K223KQ, A272P | P140PR, D237EK |
| >CA19980| codons 1-274 PISPIETVPVKLKPGMDGPKVKQWPLAEEKIEALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSITVLDVGDAYFSVPL DEDFRKYTAFTIPRINNETRGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTRNPDIVI CQYMDDLYVSSDLEIGQHRTKIEELREHLLKWGLTTPDKKYQQEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGI |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |