<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA7917 CA20368 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT 104
2 3TC+AZT+SQV 61
3 3TC+AZT+D4T+IDV 48
4 D4T+DDI+NVP+RTV+SQV 8
5 D4T+DDI+IDV+RTV 48
6 APV+D4T+DDI+EFV 57
7 APV+D4T+DDI+RTV 25

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82A, L90M   L10I, T12TS, I15IV, Q18QH, K20X, L63P, A71IV, I93L  
>CA20368| codons 1-99
PQITLWQRPIVSIKVGGHLXEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFVKVRQYD
QIPIEICGHKIIGTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, Q151M F116Y, K219Q K103N P225PH P14PS, V60I, K101KQ, V118I, K122E, I135T, T139TI, K166Q, I180IV, G196E, T200I, F214L, L228H, A272P, E291D  
>CA19977| codons 1-300
PISPIETVPVKLKSGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYYSIPL
DEDFRKYTAFTIPSTNNEIPGIRYQYNVLPMGWKGSPAIFQSSMTQILEPFRKQNPDIVV
YQYMDDLYVGSDLEIEQHRIKIEELRQHLLRWGLTTPDQKHQKEHPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVIPLTEEAE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005