Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7917 | CA20368 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 104 |
| 2 | 3TC+AZT+SQV | 61 |
| 3 | 3TC+AZT+D4T+IDV | 48 |
| 4 | D4T+DDI+NVP+RTV+SQV | 8 |
| 5 | D4T+DDI+IDV+RTV | 48 |
| 6 | APV+D4T+DDI+EFV | 57 |
| 7 | APV+D4T+DDI+RTV | 25 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, L90M | L10I, T12TS, I15IV, Q18QH, K20X, L63P, A71IV, I93L |
| >CA20368| codons 1-99 PQITLWQRPIVSIKVGGHLXEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFVKVRQYD QIPIEICGHKIIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M | F116Y, K219Q | K103N | P225PH | P14PS, V60I, K101KQ, V118I, K122E, I135T, T139TI, K166Q, I180IV, G196E, T200I, F214L, L228H, A272P, E291D |
| >CA19977| codons 1-300 PISPIETVPVKLKSGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYYSIPL DEDFRKYTAFTIPSTNNEIPGIRYQYNVLPMGWKGSPAIFQSSMTQILEPFRKQNPDIVV YQYMDDLYVGSDLEIEQHRIKIEELRQHLLRWGLTTPDQKHQKEHPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVIPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |