<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA7909 CA20361 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDC 52
2 3TC+D4T 122
3 3TC+D4T+IDV 43
4 3TC+D4T+NFV 48
5 3TC+D4T+NFV+SQV 118

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T L24I, K43T, F53L L10I, K20R, E35D, M36I, N37E, L63P, I64V, T74K  
>CA20361| codons 1-99
PQITLWQRPIVTIKIGGQLREALIDTGADDTVLEDIELPGRWTPKIIGGIGGLVKVRQYD
QIPVEICGHKAIGKVLVGPTPTNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y       K20R, K43E, E44A, V60I, V118I, K122E, G196E, T200A, E203D, H208Y, R211D, T286A, I293V  
>CA19968| codons 1-300
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRAKIDELRQYLWDWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005