<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA2076 CA20318 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T 31
2 D4T+IDV 48
3 D4T+NFV+NVP 23
4 3TC+AZT+NFV+NVP 10
5 3TC+ABC+AZT+EFV 30
6 D4T+DDI+RTV+SQV 45

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54IL, I84V, L90M   L19LV, K20T, E35G, M36I, R57K, Q61E, I62V, L63P, E65N, A71V, Q92QK, I93L  
>CA20318| codons 14-99
KIGGQVTEALLDTGADDTVLEGINLPGRWKPKLIGGIGGFLKVKQYDEVPINICGHKVIG
TVLVGPTPVNVIGRNLMTKLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y K219KN Y188L   T27TP, K43E, E44A, K66KR, K102M, V118I, K122E, I142IV, R211N, A272P, E291D, I293V  
>CA19922| codons 1-302
PISPIETVPVKLKPGMDGPKVKQWPLPEEKIKALVEICTELEEAGKISKIGPENPYNTPV
FAIKKRNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKMKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLLVGSDLEIGQHRTKIEELRQHLWNWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVVPLTEEAE
LE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005