Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2076 | CA20318 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T | 31 |
| 2 | D4T+IDV | 48 |
| 3 | D4T+NFV+NVP | 23 |
| 4 | 3TC+AZT+NFV+NVP | 10 |
| 5 | 3TC+ABC+AZT+EFV | 30 |
| 6 | D4T+DDI+RTV+SQV | 45 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54IL, I84V, L90M | L19LV, K20T, E35G, M36I, R57K, Q61E, I62V, L63P, E65N, A71V, Q92QK, I93L |
| >CA20318| codons 14-99 KIGGQVTEALLDTGADDTVLEGINLPGRWKPKLIGGIGGFLKVKQYDEVPINICGHKVIG TVLVGPTPVNVIGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219KN | Y188L | T27TP, K43E, E44A, K66KR, K102M, V118I, K122E, I142IV, R211N, A272P, E291D, I293V |
| >CA19922| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLPEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKRNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKMKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRTKIEELRQHLWNWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVVPLTEEAE LE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |