Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4497 | CA20312 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 61 |
| 2 | 3TC+AZT+IDV | 44 |
| 3 | DDC+SQV | 26 |
| 4 | D4T+NFV | 70 |
| 5 | 3TC+D4T+NFV | 33 |
| 6 | ABC+AZT+NVP+RTV+SQV | 65 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, I84V | L10I, I13V, K14KR, I15V, K20I, E35D, M36I, N37D, D60E, L63P, A71I |
| >CA20312| codons 1-99 PQITLWQRPIVTVRVGGQLIEALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVRQYE QIPIEICGHKIIGTVLVGPTPTNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | A62V, V75S | K101E, G190A | V35IT, K122E, I135T, K166R, E203D, L210F, R211K, A272P, K277R, L283I, I293V | K13KT, G18GR, K22KT |
| >CA19926| codons 1-300 PISPIETVPVKLTPGMDRPKVTQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLSDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIDELRQHLFKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |