<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4497 CA20312 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 61
2 3TC+AZT+IDV 44
3 DDC+SQV 26
4 D4T+NFV 70
5 3TC+D4T+NFV 33
6 ABC+AZT+NVP+RTV+SQV 65

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82T, I84V   L10I, I13V, K14KR, I15V, K20I, E35D, M36I, N37D, D60E, L63P, A71I  
>CA20312| codons 1-99
PQITLWQRPIVTVRVGGQLIEALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVRQYE
QIPIEICGHKIIGTVLVGPTPTNVIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T215Y A62V, V75S K101E, G190A   V35IT, K122E, I135T, K166R, E203D, L210F, R211K, A272P, K277R, L283I, I293V K13KT, G18GR, K22KT
>CA19926| codons 1-300
PISPIETVPVKLTPGMDRPKVTQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV
FVIKKKDSTKWRKLSDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
YQYMDDLYVASDLEIGQHRTKIDELRQHLFKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005