Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6416 | CA20285 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 86 |
| 2 | DDC | 271 |
| 3 | 3TC+D4T+IDV | 74 |
| 4 | 3TC+APV+D4T | 67 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, L76V | L10LI, I15V, E35D, N37E, I62V, L63P |
| >CA20285| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDMELPGRWKPKLIGGIGGFIKVRQYD QVPIEICGHKAIGTVVVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K43Q, R83K, V118I, T200A, E203D, R211K, L228R, K238R, I244V, A288S, E297K | S268V, Q269K |
| >CA19894| codons 1-299 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIDELRQHLWKWGFYTPDKKHQKEPPFRWMGYELHPDRWT VQPVVLPEKDSWTVNDIQKLVGKLNWAVKIYAGIKVKQLCKLLRGTKSLTEVIPLTKEA |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |