Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA643 | CA20251 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 13 |
| 2 | D4T | 8 |
| 3 | D4T+ 3TC | 12 |
| 4 | 3TC+ D4T+ SQV | 47 |
| 5 | DDI+ AZT+ NFV | 25 |
| 6 | 3TC+ D4T+ RTV+ SQV | 31 |
| 7 | AZT+ DDI+ NFV | 61 |
| 8 | ABC+ AZT+ DDI+ NFV | 4 |
| 9 | ABC+ AZT+ NFV | 9 |
| 10 | None | 14 |
| 11 | 3TC+D4T+NVP | 54 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K101E, G190A | K20R, K122E, K201R, D250DE, A272AP, P294Q |
| >CA20251| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIGQHRTRIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIQLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V |
| >CA20644| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |