Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA789 | CA20223 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 6 |
| 2 | DDC | 52 |
| 3 | 3TC+D4T | 246 |
| 4 | None | 3 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75T, M184V, T215Y | A62V | S68G, K122E, D123N, I178M, T200A, E204D, Q207D, R211K, A288S, I293V | I37L |
| >CA20223| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVELCTELEKEGKISKIGPENPYNTPV FVIKKKDGTKWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRAKIEDLRDHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L19IV, L33V, N37A, L63H, I64V, K70E, Q92K |
| >CA20610| codons 1-99 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVVEEMALPGRWKPKMIGGIGGFIKVRQYD QIHVEICGHEAIGTVLVGPTPVNIIGRNLLTKIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |