Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4782 | CA20180 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 61 |
| 2 | D4T | 44 |
| 3 | 3TC+AZT | 13 |
| 4 | 3TC+AZT+IDV | 117 |
| 5 | 3TC+AZT+NFV | 57 |
| 6 | 3TC+ABC+AZT+NFV | 57 |
| 7 | 3TC+AZT+NFV | 15 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V, T215F | D67G, K219Q | K20R, S68G, I135V, F214L, D218DE |
| >CA20180| codons 1-253 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10I, L19LI, N37D, L63P, I93L |
| >CA20568| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKAIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |