Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8042 | CA20173 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 63 |
| 2 | AZT+DDI | 10 |
| 3 | 3TC+AZT+IDV | 166 |
| 4 | ABC+D4T+EFV | 36 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, M184V, T215Y | Y188L | T39A, V90VI, V106I, I135T, I142V, S162C, T200K, I202V, E203ED, Q207E, H221HY, V245K, K275R, T286A |
| >CA20173| codons 1-288 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRKKVDELREHLLRWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIRVKQLCKLLRGAKA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10I, E35D, N37D, R41K, I62V, L63P, A71T, Q92QR, I93L, C95CF |
| >CA20562| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMDLPGKWKPKIIGGIGGFVKVRQYD QVPIEICGHKTIGTVLVGPTPANIIGRNLMTRLGFTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |