Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1158 | CA20135 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 42 |
| 2 | AZT+DDI | 10 |
| 3 | 3TC+AZT+IDV | 44 |
| 4 | AZT+IDV+NVP | 9 |
| 5 | 3TC+AZT+NFV+SQV | 35 |
| 6 | None | 10 |
| 7 | ADV+DDI+EFV+RTV+SQV | 24 |
| 8 | NFV+SQV | 15 |
| 9 | None | 14 |
| 10 | 3TC+ADV+AZT+EFV | 25 |
| 11 | None | 58 |
| 12 | 3TC+D4T+EFV | 9 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K103N, Y188L | K43N, K122E, E138A, I142V, S162C, I202V, R211Q, L228R, V245VE | E42EA |
| >CA20135| codons 1-262 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELANEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNATPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRTKVEELRQHLWQWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L23LI | L10LI, E35D, R41RK, D60E, I62V, L63P |
| >CA20525| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTVLEDMNLPGKWKPKMIGGIGGFIKVRQYE QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |