Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4375 | CA20127 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 25 |
| 2 | AZT+3TC | 21 |
| 3 | D4T+3TC+IDV | 56 |
| 4 | 3TC+AZT+DDI+IDV+NVP | 12 |
| 5 | D4T+DLV+NFV+SQV | 107 |
| 6 | 3TC+ABC+D4T+DDI | 81 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W, T215Y | K219R | Y188L | A98G | K20R, T39TA, E44D, V60VI, V118I, K122E, I142V, Q197E, T200A, I202V, E203K, H208Y, K223Q, V245E |
| >CA20127| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLLVGSDLEIGEHRAKVKELRQYLWRWGFYTPDRKHQQEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, I84IV, L90M | K43T | L10I, E35D, M36I, R41RK, I62V, L63Q, I64V, A71AV, I93IL, C95CS | F53SY, G68GA |
| >CA20523| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGKWTPKIIGGIGGSVKVRQYD QVQVEICAHKVIGTVLVGPTPFNVIGRNLMTQLGSTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |