Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8009 | CA20119 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 196 |
| 2 | AZT+DDC | 140 |
| 3 | 3TC+DDI+IDV | 180 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, M184V, L210W | T215D | E6EK, K20R, V60I, V118I, K122E, I135V, E169K, K173E, Q174QR, D177E, T200A, Q207E, R211K, A272P, K275R, T286A | A299AG |
| >CA20119| codons 1-303 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFRERNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLWKWGFDTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGAKALTEVIPLTEEGE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, L76LV, V82A | L24I, Q58QE | L10I, I15IV, K20KR, E35ED, M36I, N37D, R41RK, K45KN, I62V, L63P, I64V, A71AV, I72V, I93L |
| >CA20508| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEDIDLPGKWKPNIIGGIGGFVKVREYD QVPVEICGHKVVGTVVVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |