Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1556 | CA20092 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 109 |
| 2 | AZT+DDC | 14 |
| 3 | DDI | 27 |
| 4 | D4T | 21 |
| 5 | 3TC+AZT | 58 |
| 6 | 3TC+AZT+IDV | 48 |
| 7 | D4T+NFV | 25 |
| 8 | DDC+NFV+RTV+SQV | 16 |
| 9 | 3TC+RTV+SQV | 5 |
| 10 | ABC+EFV+RTV+SQV | 44 |
| 11 | ABC+APV+D4T+RTV | 37 |
| 12 | 3TC+EFV+NVP | 15 |
| 13 | 3TC+EFV+LPV+NVP | 47 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69A_SG, L74V, M184V, L210W | A62V, D67E, T215C | L100I, K103N | K43E, K64R, V111I, K122E, I135T, S162Y, R211RK, H221HY, L228H, V245E, A272P |
| >CA20092| codons 1-272 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FVIRKKESAKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDIGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFCTPDKKYQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I54V, I84V, L90M | L33F, G73S, L89V | I15V, L19P, K20T, E35G, M36I, K43KQ, I62V, L63P, A71I, P79A |
| >CA20481| codons 14-99 KVGGQPTEALLDTGADDTIFEGINLPGRWQPKMIGGIGGFVKVRQYDQVPIEICGHKIIS TVLVGATPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |