<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5423 CA20089 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDC 61
2 D4T+DDC 57
3 3TC+D4T+SQV 17
4 3TC+D4T+RTV 61
5 D4T+NVP+SQV 78
6 3TC+D4T+RTV 39
7 ABC+EFV+IDV+RTV 17
8 None 30

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    Y181C, G190GA   K11KT, W88C, D121H, K122E, I135T, D177E, H208HY, R211RK, H221Y, V245E, A272P, A288G, E291D, E297K V254VI, L260L*
>CA20089| codons 1-298
PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
CQYMDDLYVASDLEIGQHRTKIEELRQYLLKWGFTTPDKKYQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTINDIQK*VGKLNWASQIYPGIKVKQLCKLLRGTKGLTDVIPLTKE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90LM   R41K, D60E, L63P  
>CA20477| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYE
QIPIEICGHKAIGTVLVGPTPVNIIGRNLMTQIGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005