<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA7984 CA20074 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T+DDI 13
2 3TC+D4T+NFV 44
3 3TC+D4T+NFV+NVP 21
4 APV+D4T+RTV 71

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y   Y181C V108I R83K, K101KR, K122P, D177E, V179I, T200A, R211RK, H221HY, L228LR, D250E, A272P L260L*
>CA20074| codons 1-286
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLRKKKSVTILDVGDAYFSVPL
DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII
CQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKYQKEPPFRWMGYELHPDKWT
VQPIVLPEKESWTVNDIQK*VGKLNWASQIYPGIKVKQLCKLLRGT

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54M, I84IV, L90M   K20I, N37S, R57K, I62V, L63P, A71AV, T74S, V77I, V82VI, I93L  
>CA20449| codons 14-99
KIGGQLIEALLDTGADDTVLEEMSLPGRWKPKIIGGIGGFMKVKQYDQVPIEICGHKVIG
SVLIGPTPINVIGRNLMTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009