Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7963 | CA20040 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 78 |
| 2 | D4T | 17 |
| 3 | 3TC+AZT | 17 |
| 4 | 3TC+AZT+RTV | 8 |
| 5 | 3TC+AZT+IDV | 13 |
| 6 | 3TC+AZT+SQV | 26 |
| 7 | 3TC+D4T+RTV | 25 |
| 8 | 3TC+D4T+NFV | 170 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219Q | E6D, V35IM, E44D, D123DE, S162A, D177E, V179VI, G196E, E203D, H208Y, R211K, D218E, K277R, R284RK, I293V, E297A |
| >CA20040| codons 1-300 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEIII YQYVDDLYVGSDLEIEQHRTKIDELRQYLWKWGFYTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLKGTKALTEVVPLTAEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82F, L90M | K43T | L63A, A71T, V77I | R8R* |
| >CA20433| codons 1-99 PQITLWQ*PLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWTPKIIGGIGGFIKVRQYD QIAIEICGHKTIGTVLIGPTPFNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |