Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3910 | CA20021 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 72 |
| 2 | AZT+ D4T | 29 |
| 3 | 3TC+ SQV+ AZT | 67 |
| 4 | D4T+ 3TC+ NFV | 32 |
| 5 | RTV+ SQV+ NVP | 70 |
| 6 | EFV+ DDI | 30 |
| 7 | RTV+ SQV+ ABC | 50 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | Y181C, G190A | E6EK, K20R, V35T, T39A, K43Q, E44D, K101T, K102Q, K122E, S163SR, T200TI, Q207E, H208Y, R211K | L168LV |
| >CA20021| codons 1-285 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLTQKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSRMTKIVEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRIKIEELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | L23I | L10I, P39A, D60DE, I62IV, L63P, A71V, V77I |
| >CA20414| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTVLEEMNLAGRWKPKLIGGIGGFVKVRQYE QVPIEICGHKVIGTVLIGPTPANVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |