Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1461 | CA19942 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 30 |
| 2 | DDI+ AZT | 17 |
| 3 | DDC+ AZT | 40 |
| 4 | SQV+ DDC+ AZT | 103 |
| 5 | 3TC+ AZT | 14 |
| 6 | IDV+ D4T+ 3TC | 34 |
| 7 | DDI+ NVP+ D4T | 23 |
| 8 | SQV+ RTV | 60 |
| 9 | NFV+ SQV+ 3TC+ DDI | 28 |
| 10 | ABC+ DDI+ NFV+ SQV | 25 |
| 11 | AZT+ DDI+ EFV | 61 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215FY | V75L, K219KN | Y181C, G190S | K20R, V21I, V35I, T39A, E40F, K43E, K101Q, V118I, K122E, D177E, I178M, T200A, Q207E, H208Y, R211K, L228H, A272P, K277R, L283I, I293V, E297K |
| >CA19942| codons 1-298 PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALIEICAFLEEEGKISKIGPENPYNTPV FAIKKKNSDKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI CQYMDDLYVSSDLEIGQHRAKIEELREYLWKWGFFTPDNKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTKE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10F, L33F, F53L, T74P | G16A, I62V, L63P, A71V, V77I, I93L |
| >CA20335| codons 1-99 PQITLWQRPFVTIKIAGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGLIKVRQYD QVPIEICGHKVIGPVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |