<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA7859 CA19895 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 83
2 3TC+AZT 35
3 3TC+AZT+NFV 96
4 D4T+IDV+NVP 17
5 ABC+APV+DDI 71

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y   Y188L   T69N, D121CY, K122E, I135V, I142V, S162C, V179I, T200I, I202V, Q207QH, V245VL, A272P, K277R, L283I, K287KQ, A288T, I293V  
>CA19895| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
CEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII
YQYVDDLLVGSDLEIGQHRIKVEELRHHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPILLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTQTLTEVVPLTEEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54M, I84V, L90M L33F L10I, I13V, K20T, L63P, A71V, T74S, V77I, I93L  
>CA20286| codons 1-99
PQITLWQRPIVTVKIGGQLTEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFMKVRQYD
QIPIEICGHKVIGSVLIGPTPVNVIGRNLMTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005