Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SD-6 | SD-6_5 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | 3TC+ D4T+ IDV | 52 |
| 3 | NFV+ SQV+ ABC+ 3TC | 4 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | D67G, T215TA, K219Q | K20R, S68G, K122E, I135IT, I202IV, Q207AE, R211KQ, T286A |
| >SD-6_5| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRAHLLKWGFATPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, L90M | L10I, E35D, N37D, I62V, L63P, A71V, I72E, I93L |
| >SD-6_5| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKVEGTVVVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Parkin, NT | Loss of antiretroviral drug susceptibility at low viral load during early virological failure in treatment-experienced patients. | AIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |