Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SD-2 | SD-2_18 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | 3TC+ AZT+ IDV | 52 |
| 3 | NFV+ SQV+ ABC+ D4T | 17 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | A98G | T39K, K43E, S68G, I135V, S162C, R211K, L228H, V245E, A272P, K277R, V292I, I293IV |
| >SD-2_18| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, L90M | G73C | L10LI, I62V, L63P, I72E, I93L |
| >SD-2_18| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QVPIEICGHKAECTVLVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Parkin, NT | Loss of antiretroviral drug susceptibility at low viral load during early virological failure in treatment-experienced patients. | AIDS, 2000 |
| Rhee, SY | Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing. | AAC, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |