<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LVMP1270 LVMP1270 France 1999 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, I13V, G16E, E35D, M36I, R41K, K45R, L63Q, H69K, L89M  
>LVMP1270| codons 1-99
PQITLWQRPVVTVKIEGQLKEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVRQYD
QIQIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K11T, V35T, T39N, E40D, K122E, D123S, A158S, K173T, D177E, T200A, E203D, Q207A, V245Q, L260I, A272P, T286A, E291D, I293V, P294T, E312D, I326V, G335E, M357K, R358G, G359S, E370A, A371V, I375V, T377I, K390R, T403M  
>LVMP1270| codons 1-421
PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALTEICNDMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRTQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIDELRAHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKIVGKLNWASQIYPGIKVKQLCKLLRGAKALTDVVTLTEEAE
LELAENREILKDPVHGVYYDPSKDLVAEIQKQGQEQWTYQIYQEPFKNLKTGKYARKGSA
HTNDVKQLTAVVQKVAIESIVIWGKTPKFRLPIQKETWEAWWMEYWQATWIPEWEFVNTP
P

References
Author Title Citation
Vergne, L Genetic diversity of protease and reverse transcriptase sequences in non-subtype-B human immunodeficiency virus type 1 strains: evidence of many minor drug resistance mutations in treatment-naive patients. J Clin Microbiol, 2000