<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LVEQS39 LVEQS39 DRC 1997 HIV1 G PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, Q18R, L19I, K20I, M36I, N37D, R41K, L63M, C67S, H69K, V82I, L89M  
>LVEQS39| codons 1-99
PQITLWQRPLVTVKIGGRIIEALLDTGADDTVLEEIDLPGKWKPKMIGGIGGFIKVRQYD
QIMIEISGKKAIGTVLVGPTPINIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39N, E40D, V60I, A98S, K122E, I135V, K173A, Q174K, D177E, E194K, T200A, Q207E, V245E, A272P, K277R, E291D, V292I, I293V, E297A, L301M, E312D, I329L, G335D, F346Y, R356K, M357R, R358G, G359S, E370A, K390R, A400T, E404D  
>LVEQS39| codons 1-421
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNDMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI
YQYMDDLYVGSDLKIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTAEAE
MELAENREILKDPVHGVYYDPSKDLIAELQKQGQDQWTYQIYQEPYKNLKTGKYAKRGSA
HTNDVKQLTAAVQKIATESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
P

References
Author Title Citation
Vergne, L Genetic diversity of protease and reverse transcriptase sequences in non-subtype-B human immunodeficiency virus type 1 strains: evidence of many minor drug resistance mutations in treatment-naive patients. J Clin Microbiol, 2000