<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LV57HALD LV57HALD Senegal 1999 HIV1 CRF02_AG Plasma None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  V11I L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70R, L89M  
>LV57HALD| codons 1-99
PQITLWQRPVITVRIEGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35R, E36D, K122E, S162A, K173T, Q174K, D177E, I178M, V189I, T200A, Q207K, R211N, V245Q, S251N, K281R, T286A, E291D, V292I, I293V, P294T, E297G, S322T, Q334E, G335D, R356K, M357K, G359S, T369A, A371V, I375A, A376S, T386I, K390R, K395R, T403S  
>LV57HALD| codons 1-421
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALRDICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEMVI
YQYMDDLYIGSDLEIGQHRAKIEELRKHLLNWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDNWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDIVTLTGEAE
LELAENREILKEPVHGVYYDPTKDLIAEIQKQGEDQWTYQIYQEPFKNLKTGKYAKKRSA
HTNDVKQLAEVVQKASTESIVIWGKIPKFRLPIQRETWEAWWSEYWQATWIPEWEFVNTP
P

References
Author Title Citation
Vergne, L Genetic diversity of protease and reverse transcriptase sequences in non-subtype-B human immunodeficiency virus type 1 strains: evidence of many minor drug resistance mutations in treatment-naive patients. J Clin Microbiol, 2000
Diop-Ndiaye, H Antiretroviral drug resistance mutations in antiretroviral-naive patients from Senegal. ARHR, 2010