<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LVMP1152 LVMP1152 Senegal 1998 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, I13V, I15V, E35D, M36I, R41K, H69K, L89M R8Q
>LVMP1152| codons 1-99
PQITLWQQPVVTVKVGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6D, V8I, V35T, T39K, K43E, D121H, K122E, I135T, K173A, Q174K, D177E, Q207A, R211S, H221Y, K238R, V245E, K281R, T286A, E291D, V292I, I293V, P294T, E297Q, E312T, I326V, G335D, Y342F, M357K, G359S, K366R, A371V, I375V, T377L, K390R, K395R, A400T R199I
>LVMP1152| codons 1-421
PISPIDTIPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHITKIEELRAHLLSWGFTTPDKKYQKEPPFLWMGYELHPDRWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDIVTLTQEAE
LELAENREILKTPVHGVYYDPSKDLVAEIQKQGQDQWTYQIFQEPFKNLKTGKYARKRSA
HTNDVRQLTEVVQKVALESIVIWGKTPKFRLPIQRETWETWWTEYWQATWIPEWEFVNTP
P

References
Author Title Citation
Vergne, L Genetic diversity of protease and reverse transcriptase sequences in non-subtype-B human immunodeficiency virus type 1 strains: evidence of many minor drug resistance mutations in treatment-naive patients. J Clin Microbiol, 2000
Diop-Ndiaye, H Antiretroviral drug resistance mutations in antiretroviral-naive patients from Senegal. ARHR, 2010