<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LV10 LV10 Senegal 1997 HIV1 CRF09_cpx Plasma None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, I13V, M36I, R41K, K43R, H69Q, L89M  
>LV10| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLEEINLPGKWRPKMIGGIGGFIKVRQYD
QILIEICGQKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V21I, V35T, T39A, I135V, S162A, K173T, Q174K, D177E, I178M, Q207E, V245K, E248D, A272P, T286A, E291D, V292I, I293V, P294T, S322T, I326T, G335D, R356K, M357K, G359S, A371V, I375V, V381I, E399D, A400V, T403A, E432D, L452V, R461K, V467I, S468T, D471E, T473A, Q480H, L491S, Q509H, K512R, S519N, Q524K, K527E, L533M, A534S H198P, E438A, R463I, T472P, E523K
>LV10| codons 1-543
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEMVI
YQYMDDLYVGSDLEIGQPRTKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVTLTEEAE
LELAENREILKEPVHGVYYDPTKDLTAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA
HTNDVKQLTEVVQKVATESIIIWGKTPKFKLPIQKETWDVWWAEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAATFYVDGAANRETKVGKAGYVTDKGIQKVITLTEPANQKTELH
AIHLALQDSGSEVNIVTDSQYALGIIQAHPDRSESELVNQIIKKLIEKEKVYMSWVPAHK
GIG

References
Author Title Citation
Vergne, L Genetic diversity of protease and reverse transcriptase sequences in non-subtype-B human immunodeficiency virus type 1 strains: evidence of many minor drug resistance mutations in treatment-naive patients. J Clin Microbiol, 2000
Diop-Ndiaye, H Antiretroviral drug resistance mutations in antiretroviral-naive patients from Senegal. ARHR, 2010