<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LVMP576 LVMP576 Cameroon 1997 HIV1 F PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12A, K14I, I15V, L19Q, K20R, E35D, M36I, R41K, L63T, E65D, L89M  
>LVMP576| codons 1-99
PQITLWQRPLVAIIVGGQQREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QITIDICGHKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K20R, V35T, K49R, K173E, Q174K, D177E, Q207E, P243A, V245Q, D250S, A272P, Q278H, T286A, E291D, V292I, I293V, E297A, L303M, Q334H, G335D, F346H, R356K, M357R, R358S, G359S, E370N, S379G, T386V, K390R, A400T  
>LVMP576| codons 1-421
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREKNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQAIQLPEKSSWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGAKALTDIVPLTAEAE
LEMAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPHKNLKTGKYAKRSSA
HTNDVKQLTNAVQKIATEGIVIWGKVPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP
P

References
Author Title Citation
Vergne, L Genetic diversity of protease and reverse transcriptase sequences in non-subtype-B human immunodeficiency virus type 1 strains: evidence of many minor drug resistance mutations in treatment-naive patients. J Clin Microbiol, 2000