Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LBJ18 | LBJ18D_0 | Denmark | 1998 | HIV1 | B | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | aAPA+3TC+AZT+D4T+DDI+IDV+RTV+SQV | NA |
| 2 | NVP+ABC+DDI+NFV | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, L210W, T215Y | Y181C | A98G | V35I, K43Q, E44D, K122E, I135V, G196E, T200I, Q207E, H208Y, R211K, E248K, D250N | T253E |
| >LBJ18D_0| codons 1-253 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIEQHRIKIEELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPKKNSWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, N37ND, I62V, L63P, E65D, I93L |
| >LBJ18D_0| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVPIDICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Jorgensen, LB | Genotypic and phenotypic nevirapine resistance correlates with virological failure during salvage therapy including abacavir and nevirapine. | Antivir Ther, 2000 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |