Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CB-314 | CB-314 | Italy | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT| 3TC| DDI| DDC| D4T| IDV| RTV| NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | A62V | K103N, Y181C | T7P, P14PS, K43E, E44A, K66KR, T69TI, D123E, D177E, H208Y, R211K, K223KE, L228R |
| >CB-314| codons 1-253 PISPIEPVPVKLKSGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FVIKKRDSIKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQEEPPFRWMGYELHPDKWT VQPIVLPEKDSWT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V | L10F | I15V, K20R, M36I, D60E, I62IV, L63P |
| >CB-314| codons 1-99 PQITLWQRPFVTIKVGGQLREALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYE QVPIEICGHKAIGTVLVGPTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Balotta, C | Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1 infected Italian patients with virologic failure. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |