Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CB-293 | CB-293 | Italy | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT| 3TC| DDI| DDC| D4T| IDV| SQV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, V82A, L90M | G73S | T31X, L63P, A71V | G17GR |
| >CB-293| codons 17-99 RQLKEALLDTGADDXILEEMNLPGRWKPKLIGGIGGFIKVRQYDQIPIEICGHKVISTVL VGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | T27S, S48E, I50IM, T69N, R83K | L80LF, P225PL |
| >CB-293| codons 1-240 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTEMEKEGKIEKMGPENPYNTPV FAIKKKDSNRWRKLVDFREFNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKELPFLWMGYELHPDKWT |
References
| Author | Title | Citation |
| Balotta, C | Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1 infected Italian patients with virologic failure. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |