Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CB-285 | CB-285 | Italy | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT| 3TC| DDI| DDC| D4T| IDV| NFV| RTV| SQV| NVP | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73S | L10I, I15V, E35D, M36V, N37E, D60E, I62V, L63P, A71V, I72M, V77I, I85V |
| >CB-285| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDVELPGRWKPKMIGGIGGFIKVRQYE QVPIEICGHKVMSTVLIGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | Y181YC, G190GA | K20KR, T107TP, V118I, D123A, E203K, Q207E, H208Y, R211K, K223Q | N81NT, E89EK |
| >CB-285| codons 1-250 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELTKRTQDFWKVQLGIPHPAGLKKKKSVPVLDVGDAYFSIPL DKAFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIKELREYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPEKD |
References
| Author | Title | Citation |
| Balotta, C | Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1 infected Italian patients with virologic failure. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |