Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CB-246 | CB-246 | Italy | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT| 3TC| DDI| DDC| D4T| ABC| IDV| NFV| RTV| SQV| NVP | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | T12S, I15V, L19Q, K20I, M36I, N37ND, L63P, H69K, A71V, I93L |
| >CB-246| codons 1-99 PQITLWQRPLVSIKVGGQQIEALLDTGADDTVLEEIDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGKKVIGTVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | K103N, Y181C | V35I, E36EK, T39A, S48E, R83K, D123E, I135T, Q174H, G196E, T200A, Q207K, R211T, F214L, V245E |
| >CB-246| codons 1-245 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIKICAEMEKEGKIEKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI CQYMDDLYVGSDLEIEQHRAKIEELRKHLLTWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIE |
References
| Author | Title | Citation |
| Balotta, C | Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1 infected Italian patients with virologic failure. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |