<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 LPV+RTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V   I13V, G17D, K20R, E35D, M36I, R41K, R57K, D60E, I62V, L63I, H69K, L89M  
>67784| codons 1-99
PQITLWQRPLVTVKIGDQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVKQYE
QVIIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
  N348NI     E6D, V35T, V60I, D121Y, K122E, I135A, E138A, D177E, V179I, Q207E, V245EK, D250E, A272Q, L282C, G335D, P345Q, F346Y, R356K, R358K, G359S, V365I, L368LV, A376AS, T377Q, T386I, K390R  
>67784| codons 1-399
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSANNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII
YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKESWTVNDIQKLVGKLNWASQIYQGIKVKQLCKCLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEQYKILKTGKYAKMKSA
HTNDIKQVTEAVQKISQESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Barber, TJ Frequency and patterns of protease gene resistance mutations in HIV-infected patients treated with lopinavir/ritonavir as their first protease inhibitor. J Antimicrob Chemother, 2012