<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 LPV+RTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I54V, V82A   L10I, T12S, I15V, L19V, M36I, R41K, K45KR, L63P, H69K, T74S, I93L  
>65994| codons 1-99
PQITLWQRPIVSIKVGGQVKEALLDTGADDTVLEEINLPGKWKPRIIGGIGGFVKVRQYD
QIPIEICGKKAIGSVLVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67DN, M184V, T215Y     A98AG K20R, V35T, T39DE, E44ED, S48T, V60I, K122E, D123DN, K173A, T200A, Q207E, D218DE, V245T, A272P, T286A, E291D, V292I, Q334N, G335D, R356K, M357R, R358RK, G359T, A360AT, A371V, I375IV, T377R, T386TI, K390R  
>65994| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEELEKDGKITKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFYTPEKKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKRKTT
HTNDVKQLTEVVQKVARESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Barber, TJ Frequency and patterns of protease gene resistance mutations in HIV-infected patients treated with lopinavir/ritonavir as their first protease inhibitor. J Antimicrob Chemother, 2012