<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 LPV+RTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A   I13V, K14R, K20I, M36I, R41K, I64L, H69K, K70R, L89M  
>66051| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFVKVRQYD
QILLEICGKRAIGTVLVGPTPANIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, M184V       V35T, T39L, K126KR, V148VG, S162A, E169EK, Q174D, D177E, I178M, T200A, Q207E, V245Q, P247T, E248D, D250E, S251T, A272P, Q278H, K281R, E291D, V292I, I293V, E297A, L301M, S322A, I326V, I329L  
>66051| codons 1-333
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICLEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRRYTAFTIPSINNETPGIRYQYNGLPQGWKGSPAIFQASMTKILKPFRKDNPEMVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLTDKETWTVNDIQKLVGKLNWASQIYPGIKVKHLCRLLRGTKALTDIVPLTAEAE
MELAENREILKEPVHGVYYDPAKDLVAELQKQG

References
Author Title Citation
Barber, TJ Frequency and patterns of protease gene resistance mutations in HIV-infected patients treated with lopinavir/ritonavir as their first protease inhibitor. J Antimicrob Chemother, 2012