<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 LPV+RTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47A L10F, L33I, L89V I13V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, K70R, T74S  
>48826| codons 1-99
PQITLWQRPFVTVKIGGQLREALLDTGADDTIIEDINLPGKWKPKIAGGIGGFIKVKQYD
QVLIEICGKRAIGSVLVGPTPVNIIGRNVLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74LV, T215F V75I, K219E Y181C, G190A A98G, V108I P4PS, V35T, S48T, L109I, K122E, D123N, K173S, D177E, I178L, V179I, T200A, I202T, Q207A, H221Y, K223KR, L228H, V245Q, E248D, K275Q, E291D, I293V, P294T, E297R, E312D, G335D, E344D, R356K, M357R, G359T, L368I, T369TA, A371V, I375V, A376V, T377M  
>48826| codons 1-399
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKITKIGPENPYNTPV
FAIKKKNSTRWRKVIDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTIIDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSQNPELII
CQYMDDLYVASDLEIGQHRAKTEELRAHLLRWGFFTPDEKYQREPPFHWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIQVKQLCKLLRGTKALTDVVTLTREAE
LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQDPFKNLKTGKYAKRRTA
HTNDVKQIAEVVQKVVMESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Barber, TJ Frequency and patterns of protease gene resistance mutations in HIV-infected patients treated with lopinavir/ritonavir as their first protease inhibitor. J Antimicrob Chemother, 2012