Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CB-187 | CB-187 | Italy | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT| 3TC| DDI| DDC| D4T| IDV| RTV| SQV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10I, G17D, E34Q, M36L, L38W, I62V, L63P, A71V, I72Q, I93L, T96TS |
| >CB-187| codons 1-99 PQITLWQRPIVTIKIGDQLKEALLDTGADDTVLQELNWPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKVQGTVLVGPTPANIIGRNLMTQLGCSLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | A62V | T27TA, K43Q, E44D, K49R, V118I, K122E, E138A, S162C, Q174N, I178F, H208Y, R211K, L228H |
| >CB-187| codons 1-245 PISPIETVPVKLKPGMDGPKVKQWPLAEEKIKALVEICTELEQDGKISRIGPENPYNTPV FVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKNNPDFVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIV |
References
| Author | Title | Citation |
| Balotta, C | Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1 infected Italian patients with virologic failure. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |