Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CB-160 | CB-160 | Italy | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT| 3TC| DDI| DDC| D4T| IDV| RTV| SQV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75T, L210W, T215Y | F77FL, K219R | K20R, I31IL, V35I, R83K, V148G, K166R, Q207QE, H208Y, R211K, K223Q | Q91QK, A114AE, S117S*PQ |
| >CB-160| codons 1-233 PISPIETVPVKLKPGMDGPRVKQWPLTEEKLKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDKWRKLTDLRELNKKTQDFWEVKLGIPHPAGLKKKKSVTVLDVGDEYFQVPL DKDFRKYTAFTIPSINNETPGIRYQYNGLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREYLWKWGFYTPDRKHQQEPPFLWMGYE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, F53L | L10I, N37ST, R41K, D60E, L63P, H69Y, A71V |
| >CB-160| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMSLPGKWKPKLIGGIGGLVKVRQYE QIPIEICGYKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Balotta, C | Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1 infected Italian patients with virologic failure. | JAIDS, 2000 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |