Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CB-140 | CB-140 | Italy | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT| 3TC| DDI| DDC| D4T| IDV| SQV| RTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | G73S | L10I, T12P, I15IV, L19I, K20I, M36MI, N37S, I62IV, L63P, A71V, I72L |
| >CB-140| codons 1-99 PQITLWQRPIVPIKVGGQIIEALLDTGADDTVLEEISLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKVLSTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74LV, M184V, L210W, T215Y | Y181C, G190A | V35X, T39TA, K102R, K122E, I135T, F171FY, V179I, G196E, R211K, K223Q | K13KN |
| >CB-140| codons 1-236 PISPIETVPVKLNPGMDGPKVKQWPLTEEKIKALXEICAELEKEGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPYRKQNPDIII CQYVDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQQEPPFLWMGYELHP |
References
| Author | Title | Citation |
| Balotta, C | Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1 infected Italian patients with virologic failure. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |