<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CB-129 CB-129 Italy 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT| 3TC| DDI| DDC| D4T| IDV| RTV| SQV NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M   L10V, T12P, K14R, N37D, L63P, A71T, I93L, C95F  
>CB-129| codons 1-99
PQITLWQRPVVPIRIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFVKVRQYD
QIPIEICGHKTIGTVLVGPTPANIIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, L210W, T215Y K219R     V35L, T39K, K43E, E44D, T69TI, T107TP, V111I, V118I, K122E, S134SR, I135T, I142V, I178L, G196E, E203D, H208Y, R211K, K223Q L80LF
>CB-129| codons 1-238
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICKELEEDGKISKIGPENPYNTPV
FAIKKKNSIKWRKIVDFREFNKRTQDFWEVQLGIPHPAGLKKKKSVPVLDIGDAYFSIPL
DEDFRKYTAFTIPRTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIEQHRTKIDELRQYLWKWGFYTPDRKHQQEPPFLWMGYELHPDK

References
Author Title Citation
Balotta, C Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1 infected Italian patients with virologic failure. JAIDS, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005