<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CB-148 CB-148 Italy 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT| 3TC| DDI| DDC| D4T| RTV| SQV NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y   K101E   E44D, A98S, V118I, K122KE, E138A, T139E, I142T, K166KR, Q174E, D177G, T200A, Q207K, H208Y, R211K, K223KQ, V245E  
>CB-148| codons 1-253
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNAEPGTRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKENPGIVI
YQYVDDLYVGSDLEIGQHRAKIEELRKYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIELPEKDSWT

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, I84V, L90M Q58E L10I, I15V, K20L, M36I, R41K, D60DE, L63P, A71V  
>CB-148| codons 1-99
PQITLWQRPIVTIKVGGQLLEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFVKVREYE
QIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF

References
Author Title Citation
Balotta, C Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1 infected Italian patients with virologic failure. JAIDS, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005