Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CB-148 | CB-148 | Italy | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT| 3TC| DDI| DDC| D4T| RTV| SQV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K101E | E44D, A98S, V118I, K122KE, E138A, T139E, I142T, K166KR, Q174E, D177G, T200A, Q207K, H208Y, R211K, K223KQ, V245E |
| >CB-148| codons 1-253 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNAEPGTRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKENPGIVI YQYVDDLYVGSDLEIGQHRAKIEELRKYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIELPEKDSWT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V, L90M | Q58E | L10I, I15V, K20L, M36I, R41K, D60DE, L63P, A71V |
| >CB-148| codons 1-99 PQITLWQRPIVTIKVGGQLLEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFVKVREYE QIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Balotta, C | Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1 infected Italian patients with virologic failure. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |