Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
CB-148 | CB-148 | Italy | 1999 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT| 3TC| DDI| DDC| D4T| RTV| SQV | NA |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, D67N, M184V, L210W, T215Y | K101E | E44D, A98S, V118I, K122KE, E138A, T139E, I142T, K166KR, Q174E, D177G, T200A, Q207K, H208Y, R211K, K223KQ, V245E |
>CB-148| codons 1-253 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNAEPGTRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKENPGIVI YQYVDDLYVGSDLEIGQHRAKIEELRKYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIELPEKDSWT |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
I54V, V82A, I84V, L90M | Q58E | L10I, I15V, K20L, M36I, R41K, D60DE, L63P, A71V |
>CB-148| codons 1-99 PQITLWQRPIVTIKVGGQLLEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFVKVREYE QIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF |
References
Author | Title | Citation |
Balotta, C | Prevalence of multiple dideoxynucleoside analogue resistance (MddNR) in a multicenter cohort of HIV-1 infected Italian patients with virologic failure. | JAIDS, 2000 |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |