<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB4-P145 P145-55 U.S. 1997 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 3TC+AZT 8
2 3TC+AZT+EFV 19
3 3TC+AZT+EFV+IDV 36

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L   L10R, K14R, R41K, L63P, I64V, K70R, V77I  
>P145-55| codons 1-99
PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD
QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF
>P145-55| G03 | codons 1-99 | clone G03
PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD
HIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQLGCTLNF
>P145-55| G05 | codons 1-99 | clone G05
PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDMNLPGKWKPKLIGGIGGFIKVRQYD
QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQLGCTLNF
>P145-55| G06 | codons 1-99 | clone G06
PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD
QIPVEICGHRAIGTVLIGPTPVNIIGRNLMTQIGCTLNF
>P145-55| G07 | codons 1-99 | clone G07
PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD
QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF
>P145-55| G08 | codons 1-99 | clone G08
PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD
QIPVEICGHRAIGTVLIGPTPVNIIGRNLMTQLGCTLNF
>P145-55| G09 | codons 1-99 | clone G09
PQITLWQRPRVTIRIGGQLKEALLDTGADGTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD
QIPVEICGHRAIGTVLIGPTPVSIIGRNLLTQIGCTLNF
>P145-55| G02 | codons 1-99 | clone G02
PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD
QIPVGICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF
>P145-55| G04 | codons 1-99 | clone G04
PQITLWQRPRVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD
QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, T215F K219Q Y188L   V35I, T69E, K102R, V106I, D123E, I178M, Q197H, I202V, Q207A, R211K, L228H  
>P145-55| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI
YQYMDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW
>P145-55| G08 | codons 1-229 | clone G08
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII
YQYMDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQTEPPFHW
>P145-55| G03 | codons 1-229 | clone G03
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI
YQYMDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW
>P145-55| G07 | codons 1-229 | clone G07
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV
FAIKKRNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKVGELRAHLLKWGFFTPDQKHQKEPPFHW
>P145-55| G06 | codons 1-229 | clone G06
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII
YQYMDDLLVGSDLEIGHHRTKVGELRAHLLKWGFFTPDQKHQKEPPFHW
>P145-55| G05 | codons 1-229 | clone G05
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKWKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPDMVI
YQYMDDLLVGSDLEIGQHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW
>P145-55| G02 | codons 1-229 | clone G02
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII
YQYMDDLLVGSDLEIGHHRTKVEELRAHLLKGGFFTPDQKHQKEPPFHW
>P145-55| G09 | codons 1-229 | clone G09
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSERRRKLVDFRELNKRTQDFWEVQLGIPHPAGLKWKKSITVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI
CQYMDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW
>P145-55| G04 | codons 1-229 | clone G04
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKWKKSITVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI
YQYMDDLLVGSDLEIGHHRTKVEELRAHLLKWGFFTPDQKHQKEPPFHW

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005