Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
LB4-P134 | P134-0 | U.S. | 1996 | HIV1 | B | Plasma | MMC |
Treatment History
Order | Regimen | Weeks |
1 | 3TC+AZT | 8 |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
L33I | L10P, P39Q, L63P, H69Y | R87G |
>P134-0| codons 1-99 PQITLWQRPPVTIKIGGQLKEALLDTGADDTVIEEMNLQGRWKPKMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPVNIIGGNLLTQIGCTLNF >P134-0| C08 | codons 1-99 | clone C08 PQITLWQRPPVTIKIGGQLKEALLDTGADDTVIEEMNLQGRWKPKMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPVNIIGGNLLTQIGCTLNF >P134-0| C11 | codons 1-99 | clone C11 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMNLQGRWKPKMIGGIGGFIKVRQYD QIPIEICGYKTIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
D67N, K70R, M184V | K49R, T165L, Q207E, F214L |
>P134-0| C08 | codons 1-229 | clone C08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW >P134-0| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW >P134-0| C11 | codons 1-229 | clone C11 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLR |
References
Author | Title | Citation |
Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |