<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB4-P134 P134-65 U.S. 1998 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 3TC+AZT 8
2 3TC+AZT+EFV 53
3 3TC+AZT+EFV+IDV 12

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I L33I, N88D P39Q, L63P, H69Y, A71T  
>P134-65| D03 | codons 1-99 | clone D03
PQITLWQRPLVTIKIGGQLKGALLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD
QIPIEICGYKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF
>P134-65| D07 | codons 1-99 | clone D07
PQITLWQRPLVTIKIGGQLKEAPLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD
QIPIEICGYKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF
>P134-65| D08 | codons 1-99 | clone D08
PQITLWQRPLVTIKIGGQLKGALLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD
QIPIEICGYKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF
>P134-65| D10 | codons 1-99 | clone D10
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD
QIPIEICGYKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF
>P134-65| D11 | codons 1-99 | clone D11
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD
QIPIEICGYKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF
>P134-65| D02a | codons 1-99 | clone D02a
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLQGRWKPKMIGGIGGFIKVRQYD
QIPVEICGYKAIGTVLVGPTPVNIIGRNLSTQIGCTLNF
>P134-65| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD
QIPIEICGYKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    K103N   K49R, T165L, E169D, Q207E, F214L  
>P134-65| D11 | codons 1-229 | clone D11
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVGFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTILDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILDPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW
>P134-65| D02a | codons 1-229 | clone D02a
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLWRWGLTTPDKKHQKEPPFLW
>P134-65| D03 | codons 1-229 | clone D03
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEHPFLW
>P134-65| D10 | codons 1-229 | clone D10
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYSVLPQGWKGSPAIFQSSMLKILDPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEHPFLW
>P134-65| D08 | codons 1-229 | clone D08
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAVKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL
DKDFRKYTAFTMPSINDETPGIRYQYNVLPQGWKGSPAIFQSSMLKILDPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLITPDKKHQKEPPFLW
>P134-65| D07 | codons 1-229 | clone D07
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEHPFLW
>P134-65| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILDPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005