Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P134 | P134-65 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 53 |
| 3 | 3TC+AZT+EFV+IDV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | L33I, N88D | P39Q, L63P, H69Y, A71T |
| >P134-65| D03 | codons 1-99 | clone D03 PQITLWQRPLVTIKIGGQLKGALLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD QIPIEICGYKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF >P134-65| D07 | codons 1-99 | clone D07 PQITLWQRPLVTIKIGGQLKEAPLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD QIPIEICGYKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF >P134-65| D08 | codons 1-99 | clone D08 PQITLWQRPLVTIKIGGQLKGALLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD QIPIEICGYKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF >P134-65| D10 | codons 1-99 | clone D10 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD QIPIEICGYKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF >P134-65| D11 | codons 1-99 | clone D11 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD QIPIEICGYKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF >P134-65| D02a | codons 1-99 | clone D02a PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLQGRWKPKMIGGIGGFIKVRQYD QIPVEICGYKAIGTVLVGPTPVNIIGRNLSTQIGCTLNF >P134-65| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMNLQGRWKPKIIGGIGGFIKVRQYD QIPIEICGYKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | K49R, T165L, E169D, Q207E, F214L |
| >P134-65| D11 | codons 1-229 | clone D11 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVGFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILDPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW >P134-65| D02a | codons 1-229 | clone D02a PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLWRWGLTTPDKKHQKEPPFLW >P134-65| D03 | codons 1-229 | clone D03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEHPFLW >P134-65| D10 | codons 1-229 | clone D10 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYSVLPQGWKGSPAIFQSSMLKILDPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEHPFLW >P134-65| D08 | codons 1-229 | clone D08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAVKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTMPSINDETPGIRYQYNVLPQGWKGSPAIFQSSMLKILDPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLITPDKKHQKEPPFLW >P134-65| D07 | codons 1-229 | clone D07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEHPFLW >P134-65| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILDPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |