<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB4-P134 P134-12 U.S. 1996 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 3TC+AZT 8
2 3TC+AZT+EFV 12

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  L33I P39Q, L63P, H69Y  
>P134-12| E08 | codons 1-99 | clone E08
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMNLQGRWKPKMIGGIGGFIKVRQYD
QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
>P134-12| E03 | codons 1-99 | clone E03
PQTTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLQGRWKPKMIGGIGGFIKVRQYD
QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
>P134-12| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMNLQGRWKPKMIGGIGGFIKVRQYD
QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70R, M184V   K103N   K49R, T69S, T165I, D177G, Q207E, F214L  
>P134-12| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIKKKDSSRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPGIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW
>P134-12| E03 | codons 1-229 | clone E03
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIKKKDSSRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSLNNETPGIRCQYNVLPQGWKGSPAIFQSSMLKILEPFRKQNPGIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPEKKHQKEPPFLW
>P134-12| E08 | codons 1-229 | clone E08
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLW

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005