Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P133 | P133-0 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33I | N37S, L63P, H69Y |
| >P133-0| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P133-0| B07 | codons 1-99 | clone B07 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P133-0| B08 | codons 1-99 | clone B08 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P133-0| B12 | codons 1-99 | clone B12 PQITLWQRPLVTIKIGGQLKEALLDAGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P133-0| F11 | codons 1-99 | clone F11 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEVSLPGRWKPRMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P133-0| B01 | codons 1-99 | clone B01 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGRTLNF >P133-0| B03 | codons 1-99 | clone B03 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P133-0| B02 | codons 1-99 | clone B02 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | S68G, K122E, T139M, G196E |
| >P133-0| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLW >P133-0| B02 | codons 1-229 | clone B02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLW >P133-0| B03 | codons 1-229 | clone B03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSITKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW >P133-0| B07 | codons 1-229 | clone B07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYDVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLW >P133-0| B12 | codons 1-229 | clone B12 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGPPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRAKTEELRQHLWRWGFYTPDKKHQKEPPFLW >P133-0| B08 | codons 1-229 | clone B08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRSQYNVLPQGWKGSPAIFQSSMTKISEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLW >P133-0| B01 | codons 1-229 | clone B01 PISPIETVPVKLKPGMDGPKVKQWPSTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLW >P133-0| F11 | codons 1-229 | clone F11 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |