Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P132 | P132-71 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 23 |
| 3 | 3TC+AZT+EFV+IDV | 48 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, V82A | L10I, T12I, I13V, G16E, K20R, M36I, I62V, L63A, A71V |
| >P132-71| B07 | codons 1-99 | clone B07 PQITLWQRPIVIVKIEGQLREALLDTGADDTILEEINLPGRWKPKLIGGIGGFIKVRQYD QVATEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNL >P132-71| B04 | codons 1-99 | clone B04 PQITLWQRPIVIVKIEGQLREALLDTGADDTILEEINLPGRWKPKLIGGIGGFIKVRQYD QVAIEICGHKVIGTVLVGPTPANIIGKNLLTQIGCTLNF >P132-71| codons 1-99 PQITLWQRPIVIVKIEGQLREALLDTGADDTILEEINLPGRWKPKLIGGIGGFIKVRQYD QVAIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF >P132-71| B05 | codons 1-99 | clone B05 PQITLWQRPIVIVKIEGQLREALLDTGADDTILEEINLPGRWKPKLIGGIGGFIKVRQYD QVAIEICGHKVVGTVLVGPTPANIIGRNLLTQIGCTLNF >P132-71| B02 | codons 1-99 | clone B02 PQITLWQRPIVIVKIEGQLREALLDTGADDTILEEINLPGRWKPKLIGGIGGFIKVRQYD QVAIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF >P132-71| B08 | codons 1-99 | clone B08 PQITLWQRPIVIVKIEGQLREALLDTGADDTILEEINLPGRWKPKLIGGIGGFIKVRQYD QVAIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF >P132-71| B01 | codons 1-99 | clone B01 PQITLWQRPIVIVKIEGQLREALLDTGADDTILEEINLPGRWKPKLIGGIGGFIKVRQYD QVAIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF >P132-71| B06 | codons 1-99 | clone B06 PQITLWQRPIVIVKIEGQLREALLDTGADDTILEEINLPGRWKPKLIGGIGGFIKVRQYD QIAIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | L100I, K103N | K20R, K102R, K122E, D123E, I135T, V179I, G196E, L228H |
| >P132-71| codons 1-229 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-71| B01 | codons 1-229 | clone B01 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-71| B06 | codons 1-229 | clone B06 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-71| B05 | codons 1-229 | clone B05 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTEMEKEGEISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-71| B04 | codons 1-229 | clone B04 PISPIKTVPVKLKPGVDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-71| B07 | codons 1-229 | clone B07 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-71| B02 | codons 1-229 | clone B02 PISPIETVPVKLKPGLDGPRVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-71| B08 | codons 1-229 | clone B08 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |