Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P132 | P132-49 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 23 |
| 3 | 3TC+AZT+EFV+IDV | 26 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I | L10I, T12I, I13V, G16E, M36I, I62V, L63A, A71V |
| >P132-49| codons 1-99 PQITLWQRPIVIVKIEGQLKEALLDTGADDTILEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKVIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-49| A08 | codons 1-99 | clone A08 PQITLWQRPIVIVKIEGQLKEALLDTGADDTILEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEFCGHKVIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-49| A02 | codons 1-99 | clone A02 PQITLWQRPIVIVKIEGQLKEALLDTGADDTILEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEFCGHKVIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-49| A07 | codons 1-99 | clone A07 PQITLWQRPIVIVKIEGQLKEALLDTGADDTILEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF >P132-49| A03 | codons 1-99 | clone A03 PQITLWQRPIVIVKIEGQLKEALLDTGADDTILEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEFCGHKVIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-49| A05 | codons 1-99 | clone A05 PQITLWQRPIVTVKIEGQLKEALLDTGADDTIIEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF >P132-49| A01 | codons 1-99 | clone A01 PQITLWQRPIVIVKIEGQLKEALLDTGADDTILEEINLPGRWKPKMVGGIGGFIKVRQYD QVAIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-49| A06 | codons 1-99 | clone A06 PQITLWQRPIVIVKIEGQLKEALLDTGADDTILEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | L100I, K103N | K20R, E28K, K102R, K122E, D123E, I135T, G196E, L228H |
| >P132-49| codons 1-229 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-49| A07 | codons 1-229 | clone A07 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-49| A01 | codons 1-229 | clone A01 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKRQKEPPFHW >P132-49| A05 | codons 1-229 | clone A05 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-49| A02 | codons 1-229 | clone A02 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIKALVEICTEMEKEGEISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-49| A03 | codons 1-229 | clone A03 PISPVETVPVKLKPGMDGPRVKQWPLTKEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAVFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-49| A06 | codons 1-229 | clone A06 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFGELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-49| A08 | codons 1-229 | clone A08 PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYIGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |