Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P111 | P111-71 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 48 |
| 3 | 3TC+AZT+EFV+IDV | 23 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A | L24I | I15V, L19I, E35D, N37D, I64V, K70R |
| >P111-71| H10 | codons 1-99 | clone H10 PQITLWQRPLVTIKVGGQIKEALIDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHRAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P111-71| H11 | codons 1-99 | clone H11 PQITLWQRPLVTIKVGGQIKEALIDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHRAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P111-71| H05 | codons 1-99 | clone H05 PQITLWQRPLVTIKVGGQIKEALIDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHRAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P111-71| H12 | codons 1-99 | clone H12 PQITLWQRPLVTIKVGGQIKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P111-71| H08 | codons 1-99 | clone H08 PQITLWQRPLVTIKVGGQIKEALIDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHRAIGTVLVGPTPANIIGRNLLTQIGCTLNF >P111-71| codons 1-99 PQITLWQRPLVTIKVGGQIKEALIDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHRAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L100I, K103N | D121H, K122E, I135M, I142V, T200A, E203D |
| >P111-71| H10 | codons 1-229 | clone H10 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSMNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIDELRQQLLRWGFTTPDKKHQKEPPFLW >P111-71| H05 | codons 1-229 | clone H05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DENFRKYTAFTIPSMNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIDELRQHLLRWGFTTPDKKHQKEPPFLW >P111-71| H08 | codons 1-229 | clone H08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTALTIPSMNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIDELRQHLLRWGFTTPDKKHQKEPPFLW >P111-71| H11 | codons 1-229 | clone H11 PISPIETVPVKLKPGMDGPKVKQWPLTEGKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKRRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSMNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIDELRQHLLRWGFTTPDKKHQKEHPFLW >P111-71| H12 | codons 1-229 | clone H12 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FTIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSMNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIDELRQQLLRWGFTTPDKKHQKEPPFLW >P111-71| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSMNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIDELRQHLLRWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |